Simulations in Heart Function: Special issue on Cardiac modeling in BioMed Res. Int.

The special issue Simulations in Heart Function focuses on cardiac modeling and simulations that can contribute to improving the understanding of this multifaceted system under normal conditions and different cardiac pathologies. Multiple types of computational and mathematical models are used to describe heart function at different levels of details. For instance, relatively simple models have been employed to characterize the main properties of action potential propagation and wave dynamics in cardiac tissue, and detailed physiological models have been employed to improve our understanding of arrhythmia generation, fibrillation, and defibrillation. Coupled models of cardiac electromechanics that involve multiple scales, from intracellular to whole-organ, have been developed to describe the relation between electric signals and heart contraction.

Guest Editors: Rodrigo Weber dos Santos, Sergio Alonso, Elizabeth M. Cherry, and Joakim Sundnes.